<aside> ‼️ Best viewed on desktop.

</aside>

<aside> <img src="notion://custom_emoji/73e7706f-a1eb-475c-97e8-93e120fdd94a/1783fc8f-169f-8045-8782-007a4c3eb977" alt="notion://custom_emoji/73e7706f-a1eb-475c-97e8-93e120fdd94a/1783fc8f-169f-8045-8782-007a4c3eb977" width="40px" />

overlake.bio is an end-to-end decentralized science · DeSci · framework comprising a collection of projects in longevity and space biology research.

Contact: [email protected]

</aside>

What is my biggest hope for DeSci?

— A Medium article from 2022.

🟥 Technology


<aside> 🟪

/science

</aside>

<aside> 🟪

/pipeline

</aside>

<aside> 🟪

/publications

</aside>

<aside> 🟪

/resources

</aside>

<aside> <img src="notion://custom_emoji/73e7706f-a1eb-475c-97e8-93e120fdd94a/1783fc8f-169f-8045-8782-007a4c3eb977" alt="notion://custom_emoji/73e7706f-a1eb-475c-97e8-93e120fdd94a/1783fc8f-169f-8045-8782-007a4c3eb977" width="40px" />

De-/reconstructing the ground substance.

def ecm_turnover():
	return "eternal_youth.sol"

Fig.3-turnover-1024.png

- turnover -

</aside>

overlake · bio | Karma GAP

— On-chain funding information and updates.

🟥 Projects


<aside> 🟪

/all projects

</aside>

<aside> 🟪

Targets and interventions for physiological resilience in space

Spacefarer phenome

</aside>

<aside> 🟪

Matrix metalloproteinases for extracellular matrix rejuvenation

Enzyme engineering for crosslinked collagen turnover

</aside>

<aside> 🟪 Time-resolved matrisome signatures extracted public proteomic datasets

Extracellular matrix aging atlas

</aside>

<aside> 🟪 Engineered biologics to alleviate the glycation load

Advanced glycation end product (AGE)-degrading enzymes

</aside>

<aside> 🟪 Novel insights into translation fidelity in aging

Glycation of ribosomes as a driver of proteostasis loss

</aside>

🟥 Timeline


2025 |

🟪 Preprint v2 on SSRN

Methylglyoxal affects translation fidelity