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overlake.bio is an end-to-end decentralized science · DeSci · framework comprising a collection of projects in longevity and space biology research.
Contact: [email protected]
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What is my biggest hope for DeSci?
— A Medium article from 2022.
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De-/reconstructing the ground substance.
def ecm_turnover():
return "eternal_youth.sol"
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— On-chain funding information and updates.
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Funds attracted: $ 45,000
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Targets and interventions for physiological resilience in space
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Matrix metalloproteinases for extracellular matrix rejuvenation
Enzyme engineering for crosslinked collagen turnover
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<aside> 🟪 Time-resolved matrisome signatures extracted public proteomic datasets
Extracellular matrix aging atlas
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<aside> 🟪 Engineered biologics to alleviate the glycation load
Advanced glycation end product (AGE)-degrading enzymes
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<aside> 🟪 Novel insights into translation fidelity in aging
Glycation of ribosomes as a driver of proteostasis loss
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🟪 Preprint v2 on SSRN